Cryo-EM structures of Měnglà virus GP reveal combined Ebola- and Marburg-like epitope masking strategies for antibody evasion
Proceedings of the National Academy of Sciences of the United States of America
Latest Research
Last updated: June 6, 2026
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What Is Ebola?
JAMA
Landmark Studies
Key peer-reviewed papers that shaped our understanding of Ebola.
Foundational Virology
- Pattyn S, et al. "Isolation of Marburg-like virus from a case of haemorrhagic fever in Zaire." The Lancet, 1977. — First isolation of Ebola virus from the 1976 outbreak.
- Goldstein T, et al. "The discovery of Bombali virus adds further support for bats as hosts of ebolaviruses." Nature Microbiology, 2018. — Evidence for the bat reservoir hypothesis.
- Urbanowicz RA, et al. "Human Adaptation of Ebola Virus during the West African Epidemic." Cell, 2016. — Viral mutations increasing human transmissibility during the West Africa epidemic.
- Jacob ST, et al. "Ebola Virus Disease." Nature Reviews Disease Primers, 2020. PMID 32080199. — Comprehensive review of EVD pathophysiology, epidemiology, and management.
Clinical Disease & Treatment
- Bah EI, et al. "Clinical Presentation of Patients with Ebola Virus Disease in Conakry, Guinea." NEJM, 2015. — Clinical characterization of 80 EVD patients during the West Africa epidemic.
- Mulangu S, et al. "A Randomized, Controlled Trial of Ebola Virus Disease Therapeutics." NEJM, 2019. — The PALM trial: mAb114 and REGN-EB3 significantly reduce mortality vs. ZMapp.
- Uyeki TM, et al. "Clinical Management of Ebola Virus Disease in the United States and Europe." NEJM, 2016. — Management of imported EVD cases in high-income healthcare settings.
Vaccines
- Henao-Restrepo AM, et al. "Efficacy and effectiveness of an rVSV-vectored vaccine in preventing Ebola virus disease: final results from the Guinea ring vaccination trial." The Lancet, 2017. — 100% efficacy for Ervebo in ring vaccination — landmark vaccine trial.
- Tully CM, et al. "Safety and immunogenicity of a single-dose Ad26.ZEBOV and 8-week boost MVA-BN-Filo Ebola vaccination regimen." NEJM, 2021. — Janssen prime-boost vaccine phase 3 trial.
2014–2016 West Africa Epidemic
- WHO Ebola Response Team. "Ebola Virus Disease in West Africa — The First 9 Months of the Epidemic and Forward Projections." NEJM, 2014. — Foundational epidemiological analysis of the West Africa outbreak.
- Gire SK, et al. "Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak." Science, 2014. — Genomic tracing of the Guinea-to-Sierra Leone transmission chain.
Key Ongoing Data Sources
- CDC Ebola Disease — U.S. outbreak updates, clinical guidance, HCW resources
- WHO Disease Outbreak News — Official global outbreak declarations
- PubMed / PMC — Ebola Research — Peer-reviewed literature
- NIH NIAID Ebola — NIH-funded research and clinical trials
- ClinicalTrials.gov — Ebola Trials — Registered ongoing clinical research
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For accessible, long-form accounts of Ebola outbreaks, research, and the science behind the disease.
